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Preparation and cytocompatibility of chitosan‐modified polylactide
Author(s) -
Xiao Yumei,
Li Dongxiao,
Chen Xuening,
Lu Jian,
Fan Hongsong,
Zhang Xingdong
Publication year - 2008
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.28493
Subject(s) - chitosan , zeta potential , materials science , chemical engineering , methacrylic acid , poly(methacrylic acid) , polymer chemistry , fourier transform infrared spectroscopy , polymerization , polymer , composite material , nanotechnology , nanoparticle , engineering
Chitosan‐modified PLA (CMPLA) was fabricated to improve cytocompatibility of polylactide (PLA). PMAA‐grafted PLA (PMAA‐PLA) was obtained through α‐methacrylic acid (MAA) grafted polymerization on PLA surface with photooxidization and UV irradiation. Steady PMAA‐PLA microparticle suspension with an average size as 172.8 ± 3.6 nm and zeta potential as −95.0 ± 0.6 mV was prepared through solvent volatilization. By static electricity interaction and other interactions between PMAA‐PLA microsparticles and chitosan molecules, CMPLA was obtained. FTIR, XPS, SEM, and zeta potential analyses indicated that CMPLA was modified with chitosan molecules uniformly. Compared with the PLA control, CMPLA adapted to supporting the attachment and proliferation of L929 cells better. The obtained CMPLA was expected to be used as perfect biomaterial for tissue regeneration. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008