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The influence of preparation conditions on the characteristics of chitosan‐alginate dressings for skin lesions
Author(s) -
Rodrigues Ana Paula,
Saraiva Sanchez Elisabete Maria,
da Costa Aline Carvalho,
Moraes Ângela Maria
Publication year - 2008
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.28203
Subject(s) - chitosan , membrane , permeation , ultimate tensile strength , biomaterial , materials science , elongation , chemical engineering , composite material , polymer chemistry , chemistry , nanotechnology , biochemistry , engineering
Abstract In this work, the preparation and characterization of membranes obtained through chitosan and alginate coacervation and designed for use as wound dressings were evaluated. The influence of different stirring rates and rates of addition of chitosan solution to alginate solution on the final characteristics of the biomaterial was analyzed in detail, aiming at a simple and easily scalable membrane production protocol. The results show that membranes with dry thickness from 66 to 80 μm, wet thickness from 106 to 633 μm, tensile strength varying from 6.86 to 31.14 MPa, elongation at break from 3.97 to 8.42%, and maximum water uptake up to 19 g of water per gram of membrane and that are able to prevent the permeation of bacteria can be obtained in a fairly reproducible way by the procedure established. The membranes prepared at flow ratio of 40 mL/h and stirring equal to 100 rpm showed a high potential for use on highly exuding wounds. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008