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Gold/chitosan/pluronic composite nanoparticles for drug delivery
Author(s) -
Oh Keun Sang,
Kim Ree Sun,
Lee Jinho,
Kim Dongmin,
Cho Sun Hang,
Yuk Soon Hong
Publication year - 2008
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.27767
Subject(s) - nanoparticle , composite number , chitosan , materials science , drug delivery , colloidal gold , cationic polymerization , scanning electron microscope , nanotechnology , chemical engineering , polymer chemistry , composite material , engineering
Composite nanoparticles were prepared and characterized as a sustained delivery system for paclitaxel, an anticancer drug. Gold nanoparticles were used as building blocks for constructing the composite nanoparticles. An ionic interaction between the anionic gold nanoparticles and cationic chitosan was induced to form the composite nanoparticles. Particle size analysis, field emission scanning electron microscopy, transmittance electron microscopy, and ultraviolet–visible were used to observe the formation of the composite nanoparticles. For the application of the composite nanoparticles as a drug carrier, paclitaxel was loaded into the composite nanoparticles, and the drug‐release pattern was observed. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008