Premium
Effect of comonomer type and concentration on the equilibrium swelling and volume phase transition temperature of N ‐isopropylacrylamide‐based hydrogels
Author(s) -
Cortés J. A.,
Mendizábal E.,
Katime I.
Publication year - 2008
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.27632
Subject(s) - comonomer , self healing hydrogels , swelling , itaconic acid , acrylamide , polymer chemistry , monomer , poly(n isopropylacrylamide) , materials science , lower critical solution temperature , chemical engineering , chemistry , polymer , copolymer , composite material , engineering
The effect of incorporating a hydrophilic monomer into poly( N ‐isopropylacrylamide) (polyNIPA) hydrogels on the equilibrium swelling and the volume phase transition temperature is reported here. A nonionizable monomer (acrylamide) and three ionizable monomers (itaconic acid, 2‐ethoxyethyl monoitaconate, and 2,2‐(2‐ethoxyethyl) monoitaconate) were studied. Hydrogels with larger swelling capacity than that of the polyNIPA hydrogel were obtained. With the exception of the hydrogel containing 2,2‐(2‐ethoxyethyl) monoitaconate, which did not exhibit the de‐swelling phenomena, the rest showed a volume phase transition. The hydrogels containing 85 wt % acrylamide and 15 wt % comonomer presented the higher shrinking ratio. For some compositions, the T c of the polyNIPA hydrogel was within the desired temperature range (38–41°C) for controlled‐drug delivery in the human body. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008