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Synthesis and characterization of amphiphilic biodegradable poly(glutamic acid‐ co ‐lactic acid‐ co ‐glycolic acid) by direct polycondensation
Author(s) -
Lu Dedai,
Ren Zongli,
Zhou Tianhong,
Wang Shoufeng,
Lei Ziqiang
Publication year - 2007
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.27549
Subject(s) - glycolic acid , thermogravimetric analysis , condensation polymer , lactic acid , polyester , polymer chemistry , chemistry , nuclear chemistry , polyamide , differential scanning calorimetry , amphiphile , copolymer , organic chemistry , materials science , polymer , genetics , thermodynamics , physics , bacteria , biology
Poly(glutamic acid‐ co ‐lactic acid‐ co ‐glycolic acid) (PGLG), an amphiphilic biodegradable copolymer, was synthesized by simply heating a mixture of L ‐glutamic acid (Glu), DL ‐lactic acid, and glycolic acid with the present of stannous chloride. The unique branched architecture comprising of glutarimide unit, polyester unit, and polyamide unit was confirmed by NMR spectrum. The PGLG was soluble in many organic solvents and aqueous solution of sodium hydroxide (pH ≥ 9.0). The thermal properties were evaluated using thermogravimetric analysis and differential scanning calorimetry. Molecular weights were determined by 1 H NMR end‐group analysis and GPC, respectively, and the results indicated that the higher Glu content resulted in a decrease of the molecular weight. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008