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Preparation and evaluation of β‐TCP/polylactide microspheres as osteogenesis materials
Author(s) -
Lin Li Chun,
Chang Shwu Jen,
Kuo Shyh Ming,
Niu Gregory ChengChie,
Keng Hao Kai,
Tsai Pei Hua
Publication year - 2008
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.27309
Subject(s) - materials science , scanning electron microscope , composite number , osteocyte , microsphere , polymer , composite material , biomedical engineering , chemical engineering , chemistry , osteoblast , in vitro , medicine , biochemistry , engineering
In the osteological field, the study of repairing and recovering processes for bone tissues has been one of the major clinical research subjects. To promote the bone healing, bioactive composite materials have been employed for the filling and supporting of defects, voids or diseased parts. In this study, a series of microsphere composites made from polylactide (PLA), a biodegradable polymer, and β‐calcium phosphate (β‐TCP), an osteogenesis material, were prepared and estimated their potential applications in participation to the growth of new bone tissues on bone defects. By employing the water/oil/water (w/o/w) emulsion technique to fabricate a series of bioactive and biodegradable microspheres materials, we have found that one type of the microspheres: with diameter at 177 ± 33 μm, and enclosure of β‐TCP at 18% (wt/wt), exhibiting smooth surface by the optical microscopy and scanning electron microscopy (SEM) observations, and showing slow yet steady calcium ion release and PLA degradation by in vitro test, showed excellent repairing and recovery of the chondrocyte and osteocyte tissues on drilled defects on the condyle of New Zealand rabbits within 1 month of application. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008