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Temperature sensitive semi‐IPN microspheres from sodium alginate and N ‐isopropylacrylamide for controlled release of 5‐fluorouracil
Author(s) -
Mallikarjuna Reddy K.,
Ramesh Babu V.,
Krishna Rao K. S. V.,
Subha M. C. S.,
Chowdoji Rao K.,
Sairam M.,
Aminabhavi T. M.
Publication year - 2007
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.27305
Subject(s) - poly(n isopropylacrylamide) , fourier transform infrared spectroscopy , swelling , scanning electron microscope , differential scanning calorimetry , materials science , nuclear chemistry , copolymer , dissolution , microsphere , polymer chemistry , chemical engineering , particle size , controlled release , chemistry , polymer , nanotechnology , composite material , physics , engineering , thermodynamics
Semi‐interpenetrating network (IPN) of sodium alginate (NaAlg) and N ‐isopropylacrylamide (NIPAAm) microspheres were prepared by water‐in‐oil (w/o) emulsification method. The microspheres were encapsulated with 5‐fluorouracil (5‐FU) and release patterns carried in 7.4 pH at temperatures of 25 and 37°C. The semi‐IPN microspheres were characterized by Fourier transform infrared spectroscopy (FTIR). Differential scanning calorimetry (DSC) and scanning electron microscopic studies were done on the drug‐loaded microspheres to confirm the polymorphism of 5‐FU and surface morphology of microspheres. These results indicated the molecular level dispersion of 5‐FU in the semi‐IPN microspheres. Particle size and size distribution were studied by laser light diffraction technique. Microspheres exhibited release of 5‐FU up to 12 h. The swelling studies were carried in 1.2 and 7.4 pH buffer media at 25 and 37°C. Drug release from NaAlg‐NIPAAm semi‐IPN microspheres at 25 and 37°C confirmed the thermosensitive nature by in vitro dissolution. The micro domains have released in a controlled manner due the presence of NIPAAm in the matrix. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008