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Characteristics of waterborne polyurethane/poly( N ‐vinylpyrrolidone) composite films for wound‐healing dressings
Author(s) -
Yoo HyeJin,
Kim HanDo
Publication year - 2007
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.26970
Subject(s) - composite number , polyurethane , materials science , absorption of water , polymerization , composite material , aqueous solution , chemical engineering , polymer chemistry , chemistry , polymer , organic chemistry , engineering
For ideal wound‐healing dressings, a series of waterborne polyurethane (WBPU)/poly( N ‐vinylpyrrolidone) (PVP) composite films (transparent film dressings) were prepared by in situ polymerization in an aqueous medium. Stable WBPU/PVP composites, which had a high remaining weight greater than 98.4%, were obtained. The maximum content of PVP for stable WBPU/PVP dispersions was found to be about 15 wt %. The water absorption (%) and equilibrium water content (%) of the WBPU/PVP composite films remarkably increased in proportion to the PVP content and the time of water immersion. The maximum water absorption and equilibrium water content of the WBPU/PVP composite films were in the range of 21–158 and 22–56%, respectively. The water vapor transmission rate of the WBPU/PVP composite films was in the range of 1816–2728 g/m 2 /day. These results suggest that WBPU/PVP composite films may have high potential as new wound‐dressing materials that provide and maintain the moist environment needed to prevent scab formation and dehydration of the wound bed. By a wound‐healing evaluation using a full‐thickness rat model experiment, it was found that a wound covered with a typical WBPU/PVP composite film (15 wt % PVP) was completely filled with new epithelium without any significant adverse reactions. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008