Premium
Electrospun three‐dimensional silk fibroin nanofibrous scaffold
Author(s) -
Ki Chang Seok,
Kim Jong Wook,
Hyun Jin Ho,
Lee Ki Hoon,
Hattori Masahiro,
Rah Dong Kyun,
Park Young Hwan
Publication year - 2007
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.26914
Subject(s) - fibroin , scaffold , electrospinning , nanofiber , materials science , silk , tissue engineering , porosity , fabrication , morphology (biology) , composite material , nanotechnology , biomedical engineering , polymer , engineering , medicine , alternative medicine , pathology , biology , genetics
Practical application to three‐dimensional (3‐D) tissue culture has been limited by the structural restriction of two‐dimensional (2‐D) nature of electrospun nanofiber mat. In this study, for constructing 3‐D nanofibrous structure as real 3‐D tissue engineering scaffold, we developed new fabrication process with silk fibroin (SF) by electrospinning and evaluated the features of this SF nanofiber scaffold (SFNS) through morphological and cell‐culture analyses. Foam type of the SFNS exhibited high porosity as well as large pores and its cell proliferation well occurred inside (inner spaces of pores), which makes this suitable for 3‐D cell‐culture scaffold. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007