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Fluorocarbon‐containing hydrophobically modified poly(acrylic acid) gels as drug release system
Author(s) -
Zhao Xian,
Tian Qin,
Tang Xiaozhen
Publication year - 2007
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.26893
Subject(s) - methacrylate , acrylic acid , polymer chemistry , acrylate , fluorocarbon , ethyl acrylate , swelling , self healing hydrogels , chemical engineering , chemistry , materials science , copolymer , organic chemistry , polymer , composite material , engineering
Hydrophobically modified acrylic acid (AA) hydrogels containing fluorocarbon hydrophobic group and hydrocarbon‐modified gels using 2‐( N ‐ethylperfluorooctanesulfoamido) ethyl methacrylate (FMA), and lauryl acrylate (LA) respectively, 2‐( N ‐ethylperfluorooctanesulfoamido) ethyl methacrylate (FMA), were synthesized. Acetaminophen, with analgesic and antipyretic property, acted as the model drug. Swelling, rheological, and mechanical properties of the gels were investigated. Fluorocarbon‐modified gels show the stronger hydrophobicity than do the hydrocarbon‐modified gels, which affected the gel's drug‐releasing behavior. The drug release behavior depends on pH of the solution medium, the type of hydrophobic modification and the amount of hydrophobes. Hydrophobically modified PAA gels have higher storage modulus E ′ than the unmodified PAA gels. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007