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Synthesis functional poly(carbonate‐ b ‐ester) copolymers and micellar characterizations
Author(s) -
Chiu FangChyou,
Lai ChiaSheng,
Lee RenShen
Publication year - 2007
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.26454
Subject(s) - comonomer , copolymer , micelle , polymer chemistry , trimethylene carbonate , ring opening polymerization , lower critical solution temperature , polymer , aqueous solution , chemistry , polymerization , carbonate , monomer , critical micelle concentration , hydrolysis , materials science , organic chemistry
Functional poly(carbonate‐ b ‐ester)s were synthesized in buck by ring‐opening polymerization of the carbonate (TMC, MBC, or BMC) with tert ‐butyl N ‐(2‐hydroxyethyl) carbamate as an initiator, and then with ε‐CL (or ε‐BCL) comonomer. Subsequently, the PMMC‐ b ‐PCL with pendent carboxyl groups and the PTMC‐ b ‐PHCL with pendent hydroxyl groups were obtained by catalytic debenzylation. DSC analysis indicated that only one T g at an intermediate temperature the T g s of the two polymer blocks. A decrease T g was observed when an increase contents of ε‐CL incorporated into the copolymers. In contrast, two increased T m s were observed with increasing PCL content. The block copolymers formed micelle in aqueous phase with critical micelle concentrations (cmcs) in the range of 2.23–14.6 mg/L and with the mean hydrodynamic diameters in the range of 100–280 nm, depending on the composition of copolymers. The drug entrapment efficiency and hydrolytic degradation behavior of micelle were also evaluated. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007