Premium
Composites of polymeric gels and magnetic nanoparticles: Preparation and drug release behavior
Author(s) -
François Nora J.,
Allo Sabina,
Jacobo Silvia E.,
Daraio Marta E.
Publication year - 2007
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.26321
Subject(s) - ferrofluid , materials science , vinyl alcohol , self healing hydrogels , magnetic nanoparticles , drug delivery , nanoparticle , polymer , nanocomposite , rheology , chemical engineering , iron oxide nanoparticles , polyvinyl alcohol , magnetization , dynamic mechanical analysis , composite material , nanotechnology , magnetic field , polymer chemistry , engineering , physics , quantum mechanics
The article is concerned with the preparation of polymer–iron oxide nanocomposites and the study as drug‐delivery matrices under the influence of applied magnetic field. Biocompatible materials were prepared by incorporating an aqueous ferrofluid in poly(vinyl alcohol) and scleroglucan (SCL) hydrogels, loaded with theophylline as model drug for release studies. The in vitro release profile was obtained using a flat Franz cell and the kinetic parameters were derived applying a semiempirical power law. A magnetic characterization of nanoparticles contained in the ferrofluid was performed by obtaining the magnetization curve. For both systems, the observed drug release profiles decreased when a uniform external magnetic field is applied suggesting they can be used as environmental responsive matrices for biomedical applications. Dynamic rheological measurements show that a higher storage modulus and a more compact structure are obtained by incorporating the ferrofluid into the hydrogels. These rheological results and environmental electron scanning microscopy micrographs point to an understanding of release behavior once the magnetic field is applied. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007