Premium
Preparation of hydroxyapatite/Ca‐alginate composite microspheres via inverse suspension crosslinked method
Author(s) -
Liu Chao,
Ji Xiujie,
Zhao Kongyin,
Cheng Guoxiang
Publication year - 2007
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.25851
Subject(s) - composite number , disperser , materials science , microsphere , suspension (topology) , ethyl cellulose , suspension polymerization , phase (matter) , cellulose , chemical engineering , optical microscope , composite material , nuclear chemistry , polymer chemistry , chemistry , scanning electron microscope , copolymer , polymer , organic chemistry , mathematics , homotopy , pure mathematics , engineering
Composite microspheres were prepared with hydroxyapatite (HA) and Na‐alginate (ALG) via inverse suspension crosslinked method (ISCM). Chloroform/hexane (1 : 2 (volume)) was used as continuous phase, ethyl cellulose (EC) as disperser, mixture of HA powder and ALG solution as dispersed phase, and calcium chloride as crosslinking agent. Morphology of the composite microspheres and HA distribution state were observed by optical microscope. According to the compositions studied, the sample with 0.2 g of EC gives the best continuous phase. The sample with 25 mL/min of adding speed and 120 r/min of stirring speed gives the best adding and stirring conditions. Two kind of the composite microspheres of 50/50 and 70/30 HA/ALG were prepared via ISCM. They are with specific gravity of 1.06 and 1.15, and water content of 88 and 81%, respectively. The size of the dried microspheres is mainly in the range of 125–425 μm. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 2034–2038, 2007