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Dynamics of blood proteins adsorption onto poly (2‐hydroxyethyl methacrylate)‐silica nanocomposites: Correlation with biocompatibility
Author(s) -
Bajpai A. K.,
Mishra D. D.
Publication year - 2007
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.25654
Subject(s) - adsorption , nanocomposite , protein adsorption , biocompatibility , chemical engineering , materials science , methacrylate , ionic strength , (hydroxyethyl)methacrylate , sorption , fourier transform infrared spectroscopy , scanning electron microscope , polymer chemistry , hybrid material , bovine serum albumin , 2 hydroxyethyl methacrylate , chemistry , copolymer , polymer , chromatography , organic chemistry , composite material , aqueous solution , nanotechnology , engineering
A nanocomposite hybrid of poly(2‐hydroxyethyl methacrylate) (PHEMA) and silica (PHEMA‐Si) was prepared by sol–gel process and characterized by FTIR, environmental scanning electron microscopy (ESEM), and XRD techniques. The prepared hybrid was evaluated for its water sorption capacity and the adsorption of blood proteins such as bovine serum albumin (BSA) and fibrinogen (Fgn) was carried out on the hybrid surfaces. The dynamic nature of the adsorption process was investigated and related kinetic parameters were evaluated. The effect of factors like concentrations of protein solutions, pH, and ionic strength of the adsorption medium and chemical architecture of the hybrid were investigated on the adsorption process. The prepared hybrids were also examined for in vitro blood compatibility. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008