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Biocompatibility and antibacterial activity of chitosan and hyaluronic acid immobilized polyester fibers
Author(s) -
Jou ChiHsiung,
Yuan Ling,
Lin ShangMing,
Hwang MouChuan,
Chou WenLi,
Yu DaGuang,
Yang MingChien
Publication year - 2007
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.25549
Subject(s) - grafting , hyaluronic acid , biocompatibility , chitosan , antibacterial activity , polymer chemistry , polyester , nuclear chemistry , acrylic acid , fibroblast , fiber , chemistry , materials science , chemical engineering , polymer , bacteria , organic chemistry , biochemistry , in vitro , copolymer , genetics , engineering , biology
Poly(ethylene terephthalate) (PET) fibers were treated with 60 Co‐γ‐ray and grafted with acrylic acid. The resulting fibers were further grafted with chitosan (CS) via esterification. Afterward, hyaluronic acid (HA) was immobilized onto CS‐grafting fibers. The antibacterial activity of CS against S. aureus , E. coli , and P. aeruginosa was preserved after HA‐immobilization. After immobilizing HA, the L929 fibroblasts cell proliferation was improved forCS‐grafting PET fiber. The results indicate that by grafting with CS and immobilizing with HA, PET fibers not only exhibit antibacterial activity, but also improve the cell proliferation for fibroblast. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 220–225, 2007