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Blood compatibility and mechanical properties of oxidized‐chitosan films
Author(s) -
Yang Yuedong,
Zhou Yongguo,
Chuo Huimin,
Wang Shuyuan,
Yu Jiugao
Publication year - 2007
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.25399
Subject(s) - chitosan , scanning electron microscope , membrane , acetic acid , fourier transform infrared spectroscopy , swelling , ultimate tensile strength , materials science , chemical engineering , polymer chemistry , composite material , nuclear chemistry , chemistry , organic chemistry , biochemistry , engineering
By dipping chitosan films into saturated NO 2 –glacial acetic acid solution, the hydromethyl groups on the film surface could be oxidized to carboxyl groups and the blood compatibility of the films improved. Fourier transform infrared (FTIR) spectra indicated the presence of many COOH and COO − groups on the modified membrane surface. Scanning electron microscopy (SEM) showed that the surface of the modified membrane was rough, as compared with the chitosan film, which possessed a smooth surface. In the oxidation process, with increased dipping time of the films in saturated NO 2 –glacial acetic acid solution, the tensile strength of the films decreased slowly initially, and rapidly 10 h later. The swelling ratio of the modified chitosan film increased obvious noticeably as the degree of oxidation of the film increased. All antithrombosis and hemolysis tests and blood cell morphology observation with SEM revealed that the blood compatibility of modified chitosan membranes is superior to that of chitosan films. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007