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Controlled release of diclofenac sodium and ibuprofen through beads of sodium alginate and hydroxy ethyl cellulose blends
Author(s) -
Krishna Rao K. S. V.,
Subha M. C. S.,
Vijaya Kumar Naidu B.,
Sairam M.,
Mallikarju. N.,
Aminabhavi T. M.
Publication year - 2006
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.25087
Subject(s) - diclofenac sodium , ethyl cellulose , swelling , ibuprofen , sodium alginate , diffusion , sodium , bead , chemistry , chemical engineering , cellulose , chromatography , materials science , nuclear chemistry , polymer , organic chemistry , composite material , pharmacology , thermodynamics , medicine , physics , engineering
Controlled release of diclofenac sodium (DS) and ibuprofen (IB) drugs through sodium alginate (NaAlg)‐hydroxy ethyl cellulose (HEC) blend polymeric beads has been investigated. Beads were prepared by precipitating the viscous solution of NaAlg and HEC blend in alcohol followed by crosslinking with calcium chloride. Different formulations were developed in bead form by varying the amount of HEC, crosslinking agent, and drug concentration. Swelling studies in water, percent encapsulation of drugs, and release studies were carried out. The DS‐loaded beads have shown better release performance than the IB‐loaded beads. Diffusion parameters were evaluated from the Fickian diffusion theory. Mathematical modeling studies and drug release characteristics through bead matrices were studied by solving Fick's diffusion equation. The results are discussed in terms of drug release patterns and theoretical concentration profiles generated through matrices, considering spherical geometry of the beads. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 5708–5718, 2006