Improved pharmacokinetics and stability properties of catalase by chemical glycosidation with end‐group activated dextran | Zendy

Villalonga Reynaldo | Zendy; Valdivia Aymara | Zendy; Pérez Yunel | Zendy; Chongo Bertha | Zendy

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Improved pharmacokinetics and stability properties of catalase by chemical glycosidation with end‐group activated dextran

Author(s) -

Villalonga Reynaldo,

Valdivia Aymara,

Pérez Yunel,

Chongo Bertha

Publication year - 2006

Publication title -

journal of applied polymer science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.575

H-Index - 166

eISSN - 1097-4628

pISSN - 0021-8995

DOI - 10.1002/app.25019

Subject(s) - dextran , residue (chemistry) , chemistry , catalase , enzyme , carboxylate , derivative (finance) , chemical modification , chemical stability , chromatography , organic chemistry , polymer chemistry , financial economics , economics

Catalase was chemically modified with a monoactivated dextran derivative having a carboxylate group at its reducing end residue. The modified enzyme retained 77% of its initial specific activity and was 3‐fold more resistant to tryptic degradation. The plasma half‐life time was increased to 7.3‐fold after glycosidation. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 4573–4576, 2006

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