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Characterization of the biocide polyhexamethylene biguanide by matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry
Author(s) -
O'Malley Leon P.,
Hassan Kaneez Z.,
Brittan Helen,
Johnson Neil,
Collins Andrew N.
Publication year - 2006
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.24915
Subject(s) - mass spectrometry , biocide , chemistry , polymer , desorption , polymerization , depolymerization , amine gas treating , ion , matrix assisted laser desorption/ionization , biguanide , analytical chemistry (journal) , polymer chemistry , chromatography , organic chemistry , adsorption , medicine , metformin , diabetes mellitus , endocrinology
The biocide polyhexamethylene biguanide (PHMB) has been characterized by matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS). Previously, no method has been able to provide a detailed structural characterization of PHMB. MALDI‐TOF MS was able to detect PHMB oligomers with n ≤ 6. Six different PHMB product types were identified, which possess combinations of amine, cyanoamine, guanidine, or cyanoguanidine end‐groups. Postsource decay (PSD) fragmentation was used to confirm the correct assignment of PHMB structure for the dominant PHMB molecular ion. MALDI‐TOF MS analysis of a 15 N‐labeled PHMB confirmed the correct assignment of PHMB molecular ions, and also indicated the existence of a polymerization–depolymerization equilibrium during melt polymerization of the polymer. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 4928–4936, 2006