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Antimicrobial poly( N ‐vinyl‐2‐pyrrolidone‐ alt ‐maleic anhydride)/poly(ethylene imine) macrocomplexes
Author(s) -
Temiz Ayhan,
Özmen Toğay Sine,
Şener Ayla,
Güven Güldem,
Rzaev Zakir M. O.,
Piskin Erhan
Publication year - 2006
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.24903
Subject(s) - maleic anhydride , polymer chemistry , copolymer , chemistry , amine gas treating , vinyl acetate , polymer , succinic anhydride , antimicrobial , aqueous solution , materials science , organic chemistry
Abstract The antimicrobial polymer/polymer macrocomplexes were synthesized by radical alternating copolymerization of N ‐vinyl‐2‐pyrrolidone with maleic anhydride [poly(VP‐ alt ‐MA)] with 2,2′‐azobis‐isobutyronitrile as an initiator at 65°C in dioxane solutions under nitrogen atmosphere, and interaction of prepared copolymer with poly(ethylene imine) (PEI) in aqueous solutions. The susceptibility of some Gram‐negative ( Salmonella enteritidis and Escherichia coli ) and Gram‐positive ( Staphylococcus aureus and Listeria monocytogenes ) bacteria to the alternating copolymer and its PEI macrocomplexes with different compositions in microbiological medium was studied using pour‐plate technique. All the studied polymers, containing biologically active moieties in the form of ionized cyclic amide, and macrobranched aliphatic amine groups and acid/amine complexed fragments, were more effective against L. monocytogenes than those for Gram‐positive S. aureus bacterium. This fact was explained by different surface layer structural architectures of biomacromolecules of tested bacteria. The resulting polymeric antimicrobial materials are expected to be used in various areas of medicine and food industry. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102:5841–5847, 2006