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Biodegradable studies of poly(trimethylenecarbonate‐ε‐caprolactone)‐ block ‐poly( p ‐dioxanone), poly(dioxanone), and poly(glycolide‐ε‐caprolactone) (Monocryl®) monofilaments
Author(s) -
Hong JongTaek,
Cho NamSook,
Yoon HyeSung,
Kim TaeHun,
Koh MyoungSeok,
Kim WhanGi
Publication year - 2006
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.24440
Subject(s) - crystallinity , caprolactone , polymer chemistry , materials science , ultimate tensile strength , polymer , copolymer , biodegradation , chemistry , composite material , organic chemistry
Abstract The aim of the study was to investigate the mechanical properties and biodegradability of poly(trimethylenecarbonate‐ε‐caprolactone)‐ block ‐poly( p‐ dioxanone) [P(TMC‐ε‐CL)‐ block ‐PDO] in comparison with poly( p ‐dioxanone) and poly(glycolide‐ε‐caprolactone) (Monocryl®) monofilaments in vivo and in vitro . P(TMC‐ε‐CL)‐ block ‐PDO copolymer and poly( p ‐dioxanone) were prepared by using ring‐opening polymerization reaction. The monofilament fibers were obtained using conventional melt spun methods. The physicochemical and mechanical properties, such as viscosity, molecular weight, crystallinity, and knot security, were studied. Tensile strength, breaking strength retention, and surface morphology of P(TMC‐ε‐CL)‐ block ‐PDO, poly( p ‐dioxanone), and Monocryl monofilament fibers were studied by immersion in phosphate‐buffered distilled water (pH 7.2) at 37°C and in vivo . The implantation studies of absorbable suture strands were performed in gluteal muscle of rats. The polymers, P(TMC‐ε‐CL)‐ block ‐PDO, poly( p ‐dioxanone), and Monocryl, were semicrystalline and showed 27, 32, and 34% crystallinity, respectively. Those mechanical properties of P(TMC‐ε‐CL)‐ block ‐PDO were comparatively lower than other polymers. The biodegradability of poly(dioxanone) homopolymer is much slower compared with that of two copolymers. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 737–743, 2006