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Biologically active polymers. IV. Synthesis and antimicrobial activity of tartaric acid polyamides
Author(s) -
Kenawy ElRefaie,
AbdelHay Fouad I.,
Shahada Lamies,
ElShanshoury Abd ElRaheem R.,
ElNewehy Mohamed H.
Publication year - 2006
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.24126
Subject(s) - phosphonium , polyamide , chemistry , bacillus cereus , nuclear chemistry , antimicrobial , organic chemistry , polymer chemistry , bacteria , biology , genetics
New bactericidal polyamides with quaternary ammonium or phosphonium salts were prepared, and their antimicrobial activities were explored. The polyamides were synthesized by the polycondensation of diethyl‐ l ‐tartrate or chloromethylated diethyl‐ l ‐tartrate with ethylenediamine in dry absolute ethanol. The polyamides were modified to yield polymers with either quaternary ammonium or phosphonium salts. The polymers were characterized with elemental microanalysis and 1 H‐NMR and IR spectra. The antimicrobial activity of the polymers bearing onium salts was studied against Gram‐negative bacteria ( Escherichia coli , Pseudomones aeruginosa , Shigella sp., and Salmonella typhae ), Gram‐positive bacteria ( Bacillus subtilis and Bacillus cereus ), and a fungus ( Trichophytum rubrum ) by the cut‐plug and viable‐cell‐count methods. Although all the polymers showed high antibacterial activity, some had no antifungal activity. The tributyl phosphonium salt of the polyamide was more effective against both Gram‐negative and Gram‐positive bacteria than the triethyl ammonium and triphenyl phosphonium salts of the polyamide. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 4780–4790, 2006