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Controlled release of bovine serum albumin using MPEG–PCL diblock copolymers as implantable protein carriers
Author(s) -
Kim Moon Suk,
Seo Kwang Su,
Hyun Hoon,
Khang Gilson,
Cho Sun Hang,
Lee Hai Bang
Publication year - 2006
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.23528
Subject(s) - copolymer , bovine serum albumin , materials science , polymer chemistry , polymerization , polyethylene glycol , drug carrier , chemical engineering , drug delivery , polymer , chemistry , nanotechnology , chromatography , composite material , engineering
Abstract MPEG–PCL diblock copolymers consisting of methoxy polyethylene glycol (MPEG) and poly(ϵ‐caprolactone) (PCL) as drug carriers were synthesized by ring‐opening polymerization. It is possible to control the balance between hydrophilic and hydrophobic by changing the MPEG and the ratio of ϵ‐CL to MPEG. Implantable wafers were easily fabricated by the direct compression method after physical mixing of diblock copolymers and bovine serum albumin–fluorescein isothiocyanate (BSA‐FITC) as a model protein drug. The BSA release from wafers prepared by MPEG–PCL diblock copolymers were higher than that from PCL with the physical blending of MPEG. The wafers prepared by a variety of MPEG–PCL diblock copolymers exhibited the controlled BSA release profiles with a dependence on MPEG–PCL diblock copolymer compositions. In addition, the changing of MPEG and PCL molecular weights within MPEG–PCL diblock copolymer controlled the initial burst of BSA. We confirmed that the diblock copolymers could be served as protein delivery carrier in implantable wafer form. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102:1561–1567, 2006