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Preparation and characterization of novel pH‐sensitive binary grafted polymeric blends of gelatin and poly(vinyl alcohol): Water sorption and blood compatibility study
Author(s) -
Bajpai A. K.,
Sharma Manish
Publication year - 2006
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.23370
Subject(s) - vinyl alcohol , self healing hydrogels , polymer chemistry , differential scanning calorimetry , materials science , acrylic acid , chemical engineering , gelatin , sorption , polyelectrolyte , polymer , interpenetrating polymer network , adsorption , chemistry , copolymer , organic chemistry , composite material , thermodynamics , physics , engineering
In this study, we attempted the synthesis and characterization of novel biocompatible hydrogels of binary polymeric blends of crosslinked poly(acrylic acid) grafted onto poly(vinyl alcohol) and gelatin by a redox polymerization technique. The end polymer was characterized by IR spectral analysis, differential scanning calorimetry measurements, and scanning electron microscopy. The prepared smart, environment‐responsive hydrogels, containing polyelectrolyte domains, were assessed for their water sorption potential under various experimental conditions and were further used to evaluate important network parameters such as the crosslink density, number of elastically effective chains, and molecular mass between crosslinks. The diffusion mechanism of the solvent–polymer interaction was also analyzed to predict the behavior of continuously relaxing chains containing several carboxylate ions. The blood compatibility of premeditated hydrogels was also judged by in vitro methods such as protein adsorption, blood clot formation, and hemolysis percentage assay measurement. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 599–617, 2006