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Controlled release and absorption of cetylpyridinium chloride using polymer hydrogels
Author(s) -
Densmore Crystal G.,
Robison Thomas W.,
Smith Barbara F.,
Lewis Randall E.
Publication year - 2005
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.23210
Subject(s) - self healing hydrogels , cetylpyridinium chloride , swelling , polymer , chemical engineering , aqueous solution , materials science , methacrylate , monomer , absorption (acoustics) , (hydroxyethyl)methacrylate , polymer chemistry , chemistry , composite material , pulmonary surfactant , organic chemistry , engineering
Interest in the biocide cetylpyridinium chloride (CPC) has resurged based on new studies showing its effectiveness against a wide variety of pathogens. Hydroxyethyl methacrylate (HEMA)‐based hydrogels have been developed for the controlled release of CPC. Initial burst release of the biocide can be controlled and sustained release can be achieved for more than two weeks. The burst and sustained release can be adjusted by varying the amount of anionic monomer (AMPSA), crosslink content (DEGDMA), release media, hydrogel surface area, and CPC loading. After removing the CPC‐loaded hydrogel from solution and drying, the release of CPC can also be reactivated. Very interesting swelling behavior was observed for CPC‐loaded hydrogels due to the electrostatic and hydrophobic interactions between the polymer hydrogel and CPC. In addition, HEMA‐based hydrogels can be used to recover or absorb CPC from aqueous solutions. By increasing the amount of AMPSA in the HEMA‐based hydrogel, more CPC can be absorbed from solution. The absorption is also enhanced by agitating the solution. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006