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Preparation of high‐molecular‐weight poly( L ‐lactic acid)‐based polymers through direct condensation polymerization in bulk state
Author(s) -
Kim Hun Sik,
Hwang Mi Ok,
Kim Mal Nam,
Yoon Jin San
Publication year - 2006
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.23162
Subject(s) - lactic acid , polymer chemistry , condensation polymer , nuclear chemistry , succinic acid , ethylene glycol , ethylene oxide , materials science , molar mass distribution , polymer , chemistry , copolymer , organic chemistry , genetics , bacteria , biology
Poly( L ‐lactic acid‐ co ‐succinic acid‐ co ‐1,4‐butanediol) (PLASB) was synthesized by a direct condensation copolymerization of L ‐lactic acid, succinic acid (SA), and 1,4‐butanediol (BD) in bulk state using titanium(IV) butoxide (TNBT) as a catalyst. Weight average molecular weight ( M w ) of PLASB increased from 3.5 × 10 4 to 2.1 × 10 5 as the content of SA and BD went up from 0.01 to 0.5 mol/100 mol of L ‐lactic acid (LA). PLASB having M w in the range from 1.8 × 10 5 to 2.1 × 10 5 showed tensile properties comparable to those of commercially available poly( L ‐lactic acid) (PLLA). In sharp contrast, homopolymerization of LA in bulk state produced PLLA with M w as low as 4.1 × 10 4 , and it was too brittle to prepare specimens for the tensile tests. M w of PLASB synthesized by using titanium(IV)‐2‐ethyl(hexoxide), indium acetate, indium hydroxide, antimony acetate, antimony trioxide, dibutyl tin oxide, and stannous‐2‐ethyl 1‐hexanoate was compared with that of PLASB obtained by TNBT. Ethylene glycol oligomers with different chain length were added to LA/SA in place of BD to investigate effect of chain length of ethylene glycol oligomers on the M w of the resulting copolymers. Biodegradability of PLASB was analyzed by using the modified Sturm test. Toxicity of PLASB was evaluated by counting viable cell number of mouse fibroblast cells that had been in contact with PLASB discs. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 466–472, 2006

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