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Synthesis of a water‐soluble fullerene derivative nanoball and its biological activity
Author(s) -
Jiang Guichang,
Zheng Qixing,
Yang Dazhi
Publication year - 2005
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.22837
Subject(s) - acrylamide , copolymer , fullerene , dimethyl sulfoxide , polymer chemistry , polymerization , materials science , derivative (finance) , monomer , chemistry , organic chemistry , polymer , economics , financial economics
A novel fullerene–acrylamide copolymer was synthesized via radical polymerization. It is soluble in polar solvents such as water and dimethyl sulfoxide. The product was characterized by FTIR, UV–vis, and GPC. TEM analysis showed that the average particle diameter was about 46 nm. The in vitro antitumor activity of the fullerene–acrylamide derivatives was tested, and the results showed that the novel fullerene–acrylamide derivatives exhibited better antitumor activity in vitro against bone tumor cells. The cytotoxicity against the tumor cell mechanism of the fullerene copolymer nanoball was studied. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006