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Poly( D , L ‐lactide‐ co ‐glycolide)/poly(ethylenimine) blend matrix system for pH sensitive drug delivery
Author(s) -
Sutton Damon,
Durand Remy,
Shuai Xintao,
Gao Jinming
Publication year - 2006
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.22636
Subject(s) - differential scanning calorimetry , plga , polymer chemistry , nuclear chemistry , fourier transform infrared spectroscopy , polymer , drug delivery , swelling , materials science , glass transition , chemistry , drug carrier , chemical engineering , organic chemistry , nanotechnology , nanoparticle , composite material , physics , engineering , thermodynamics
Poly( D , L ‐lactide‐ co ‐glycolide) (PLGA) and poly(ethylenimine) (PEI) were blended and found to form a homogeneous pH sensitive matrix for drug release. Differential scanning calorimetry (DSC) studies of the PLGA/PEI blends showed a single glass transition temperature at all compositions. Fourier transform infrared spectroscopy (FTIR) demonstrated that the PLGA carbonyl peak at 1760 cm −1 shifted to 1666 cm −1 as a result of amide bond formation between the two polymers. This was confirmed by 13 C nuclear magnetic resonance studies. A PLGA/PEI matrix of 90/10 weight ratio was chosen for evaluation for controlled drug release. Both hydrophobic β‐lapachone and hydrophilic rhodamine B showed pH dependent release profiles with faster release kinetics at lower pH values. The observed pH sensitive drug release was mainly attributed to two factors, pH dependent swelling and protonation of the PEI‐PLGA matrix. These results demonstrate utility of a PLGA/PEI matrix and its potential application in pH responsive drug delivery. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 89–96, 2006