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Reacetylated chitosan/cashew gum gel: Preliminary study for potential utilization as drug release matrix
Author(s) -
Maciel Jeanny S.,
Paula Haroldo C. B.,
Miranda Marcus A. R.,
Sasaki Jose M.,
de Paula Regina C. M.
Publication year - 2005
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.22099
Subject(s) - chitosan , chemistry , controlled release , pilocarpine , diffusion , fourier transform infrared spectroscopy , nuclear chemistry , fick's laws of diffusion , matrix (chemical analysis) , natural gum , acetic anhydride , chromatography , chemical engineering , organic chemistry , polysaccharide , catalysis , physics , neuroscience , engineering , epilepsy , biology , thermodynamics
The aim of this work was to characterize and investigate the potential of chitosan/cashew gum (CH/CG) gel for the controlled release of pilocarpine hydrochloride. Gels were prepared by reacetylation of CH with acetic anhydride, characterized by infrared spectroscopy, thermal analysis, and X‐ray diffraction. Swellings in water and in phosphate buffers were also investigated. The release of pilocarpine for CH and CH/CG gels was shown to be similar in the first 100 min, where about 60% of the pilocarpine was released. After this time, addition of CG to the gels decreases pilocarpine release rate in the medium. CH gel release was found to be dependent on pH values, a non‐Fickian mechanism was observed for the release at pH 2 and 7.4, while at pH 9.8, a Fickian (diffusion) mechanism took place. On the other hand the release of pilocarpine in CH/CG matrix occurred by Fickian mechanism, independent of the pH value. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99: 326–334, 2006