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Drug‐releasing kinetics of MPEG/PLLA block copolymer micelles with different PLLA block lengths
Author(s) -
Kim Sung Yeon,
Kim Jee Heung,
Kim Dukjoon,
An Jung Ho,
Lee Doo Sung,
Kim Sung Chul
Publication year - 2001
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.2111
Subject(s) - copolymer , micelle , kinetics , dynamic light scattering , ethylene glycol , diffusion , amphiphile , polymer chemistry , chemical engineering , materials science , hydrodynamic radius , biodegradation , chemistry , aqueous solution , nanoparticle , organic chemistry , polymer , nanotechnology , composite material , thermodynamics , physics , quantum mechanics , engineering
Copolymers of poly( L ‐lactic acid) and methoxy end‐capped poly(ethylene glycol) were synthesized, and their structure and physical properties were characterized. Micellar structures were formed in aqueous media because of the amphiphilic nature of the copolymers, and their sizes were measured with both dynamic light scattering equipment and scanning electron microscopy. Indomethacin was loaded into the copolymer micelles, and its releasing behavior was monitored. The drug‐releasing mechanism was determined from an investigation of the biodegradation kinetics of the copolymer micelles. The releasing mechanism was governed by diffusion rather than a biodegradation process. We adapted a model based on Fick's diffusion theory to describe the overall releasing behavior with the extraction of the diffusion coefficient. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 2599–2605, 2001