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Synthesis of molecularly imprinted microspheres for recognition of trans ‐aconitic acid
Author(s) -
Jiang Yong,
Tong AiJun
Publication year - 2004
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.20954
Subject(s) - molecularly imprinted polymer , monomer , precipitation polymerization , polymer , monolith , polymerization , microsphere , materials science , molecule , molecular imprinting , polymer chemistry , solvent , chemical engineering , chemistry , selectivity , catalysis , radical polymerization , organic chemistry , composite material , engineering
In the presence of a template molecule, trans ‐aconitic acid and, using acetonitrile as solvent and dispersing medium, monodispersed microspheres with a diameter of 600–700 nm bearing molecularly imprinted binding sites were prepared by precipitation polymerization. It was found that the concentrations of template, monomer, and crosslinking agent as well as the chemical structure of the template greatly affect the polymer configuration. Microspheres are produced only when the concentration of the template molecule and the functional monomer are finely tuned. Comparison with the performance of a conventional imprinted polymer monolith showed that the imprinted microsphere had obvious advantages in specific binding to template molecule. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 94: 542–547, 2004