Premium
Enhanced drug uptake and retention by surface phosporylated polyvinyl alcohol
Author(s) -
Sreenivasan K.
Publication year - 2004
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.20885
Subject(s) - polyvinyl alcohol , crystallinity , surface modification , polymer , chemical engineering , drug , materials science , chemical modification , polymer chemistry , alcohol , chemistry , organic chemistry , composite material , pharmacology , medicine , engineering
Polyvinyl alcohol (PVA) is one of the widely used synthetic polymers for a variety of medical applications. Surface modification of polymers is often used to improve the surface‐mediated interactions with the bioenvironment. When phosphate groups are introduced onto the surface of PVA, the modification enhances the hydrophilicity of the polymer. A severalfold enhancement in the extent of uptake of antibacterial drugs such as ampicillin occurs as a result of the phosphorylation. It is also found that drug retention is prolonged significantly by the modification process. Interestingly, the modification did not alter bulk features like the crystallinity of the PVA. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 94: 651–656, 2004