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Diffusion‐controlled polymer dissolution and drug release
Author(s) -
Vrentas J. S.,
Vrentas C. M.
Publication year - 2004
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.20406
Subject(s) - dissolution , diffusion , polymer , amorphous solid , materials science , fick's laws of diffusion , dissolution testing , drug , chemical engineering , polymer chemistry , chemistry , thermodynamics , organic chemistry , composite material , physics , pharmacology , medicine , ethyl cellulose , engineering
Abstract A model is formulated for diffusion‐controlled polymer dissolution and simultaneous drug release for amorphous, uncrosslinked polymers. Calculated fractional drug release versus time curves are similar to experimental curves reported in the literature. Solutions of the transport equations provide a way of illustrating how polymer type and molecular weight can be used in an attempt to approach a constant drug release rate. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 92–99, 2004