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Vitamin A microencapsulation within poly(methyl methacrylate)‐ g ‐polyethylenimine microspheres: Localized proton buffering effect on vitamin A stability
Author(s) -
Lee Jong Suk,
Nam Yoon Sung,
Kang ByungYoung,
Han SangHoon,
Chang IhSeop
Publication year - 2004
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.20028
Subject(s) - polyethylenimine , polymer chemistry , methyl methacrylate , polymer , emulsion polymerization , methacrylate , acrylic acid , nuclear chemistry , materials science , poly(methyl methacrylate) , grafting , chemistry , chemical engineering , polymerization , organic chemistry , copolymer , transfection , biochemistry , engineering , gene
To stabilize vitamin A in a cosmetic/dermatological formulation, we present here a new encapsulation method based on polymer microspheres having a localized “proton‐buffering” capacity. Poly(methyl methacrylate)‐ g ‐polyethylenimine (PMMA‐ g ‐PEI) was prepared by direct condensation grafting of PEI onto poly(methyl methacrylate‐ co ‐methyl acrylic acid). The reaction was confirmed by FT‐IR analysis showing the amide vibration at 1,550 cm −1 . Elemental analysis indicated that the weight content of the grafted PEI was 1.6% (w/w). Vitamin A was encapsulated into PMMA‐ g ‐PEI microspheres by using an oil‐in‐water (O/W) single emulsion method. The presence of PEI moiety dramatically improved the chemical stability of vitamin A in microspheres. Vitamin A encapsulated within PMMA‐ g ‐PEI microspheres maintained 91% of its initial activity after 30‐day incubation at 40°C, while only maintaining 60% within plain PMMA microspheres. This study demonstrates that proton‐buffering within hydrophobic polymer matrix is a useful strategy for stabilizing “acid‐labile” active ingredients. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 92: 517–522, 2004