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Surface analysis of PP/EVA blends modified with amino acids for biomedical applications
Author(s) -
Schroeder K.,
Klee D.,
Höcker H.,
Leute A.,
Benninghoven A.,
Mittermayer C.
Publication year - 1995
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1995.070580403
Subject(s) - covalent bond , x ray photoelectron spectroscopy , polymer chemistry , chemistry , infrared spectroscopy , amino acid , surface modification , adhesion , materials science , organic chemistry , chemical engineering , biochemistry , engineering
The copolymers poly(propylene‐ co ‐ethylene) (PP/E) and poly(ethylene‐ co ‐vinyl acetate) (EVA) and blends of these were modified to develop an artificial matrix which promotes the growth of endothelial cells. Covalent immobilization of amino acids or sequences of adhesion glycoproteins should trigger the formation of an endothelial cell monolayer onto the polymeric surface. Reactive functional groups were generated by saponifying the ester groups of the EVA component. Esterification with oxalylic or malonic dichlorides in the gas phase yielded the required monoesters and gave the best results for further immobilization of amino acids, while reaction with α,ω‐dicarboxylic acid dichlorides in solution led to diester formation. Subsequently, various protected amino acids were immobilized via the carbodiimide method. Surface analytical methods like infrared spectroscopy using at tenuated total reflection (IR‐ATR), X‐ray photoelectron spectroscopy (XPS), and secondary ion mass spectrometry (SIMS) were used to prove the modification steps. The analytical results confirmed covalent side‐chain generation in the upper surface region. © 1995 John Wiley & Sons, Inc.