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Release of radioactive steroids from dried down hydrogels of polyurethane networks
Author(s) -
Zulfiqar M.,
Quddos A.,
Zulfiqar S.
Publication year - 1995
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1995.070550903
Subject(s) - self healing hydrogels , polyurethane , ethylene glycol , polymer chemistry , materials science , nuclear chemistry , in vivo , peg ratio , stoichiometry , chemical engineering , chemistry , organic chemistry , composite material , microbiology and biotechnology , finance , engineering , economics , biology
The polyurethane networks were based on poly(ethylene glycol) 6000 (PEG), crosslinked with 1,1,1‐tris(hydroxy methyl)ethane and with the stoichiometric equivalence of hexamethylene diisocyanate. Radioactive steroids were incorporated into cylindrical hydrogels over a wide range of compositions. The release profiles were drawn from dried down hydrogel of polyurethane networks. The scintillation counter was used for the release study of steroids after different intervals. In vivo , the loaded hydrogels were implanted into rats. The results for constant release studies were recorded. © 1995 John Wiley & Sons, Inc.