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Graft copolymerization of 2‐hydroxyethylmethacrylate onto chitosan films and their blood compatibility
Author(s) -
Singh D. K.,
Ray Alok R.
Publication year - 1994
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1994.070530814
Subject(s) - chitosan , copolymer , grafting , swelling , monomer , solvent , polymer chemistry , materials science , methacrylate , nuclear chemistry , chemistry , composite material , organic chemistry , polymer
This article examines the blood compatibility of chitosan grafted with 2‐hydroxyethyl‐methacrylate (HEMA) using 60 Co gamma radiation. The effect of various syntheses conditions on the grafting was determined. The solvent composition has a marked effect on the degree of grafting. Maximum yield was obtained in an equivolume mixture of a water–methanol system. The percent grafting increased with the increase in the monomer concentration up to 20 vol % in a total dose of 0.216 Mrad. The percent grafting was found to be higher at a lower dose rate for a constant total dose of 0.216 Mrad. The swelling of grafted chitosan films decreased on increasing graft level. The grafted copolymers showed improved blood compatibility as compared to original chitosan sample. © 1994 John Wiley & Sons, Inc.