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Concentration of biological liquids by dialysis with modified acrylonitrile copolymer membranes
Author(s) -
Godjevargova Ts.,
Dimov A.
Publication year - 1994
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1994.070530602
Subject(s) - acrylonitrile , membrane , copolymer , differential scanning calorimetry , hydrolysis , polymer chemistry , chemistry , chemical engineering , materials science , nuclear chemistry , organic chemistry , polymer , biochemistry , physics , engineering , thermodynamics
Acrylonitrile copolymer membranes were subjected to partial hydrolysis in order to improve their dialysis characteristics. The partial hydrolysis time and temperature, as well as the concentration of the hydrolyzing agent, were the variable parameters. The changes in the chemical and physical characteristics of the membrane were proved by infrared spectroscopy, elemental analysis, differential scanning calorimetry, and Mercury intrusion porometry. After each degree of modification, the permeability of the membrane with respect to a solution of vitamin B 12 was determined under static conditions and at temperature of 298 K. The improvement in the permeability at a definite degree of hydrolysis is explained by the conversion of nitrile groups to amide and carboxyl groups, as well as increase of the volume of the pores with average radius. The efficiency of the modified PAN membranes for concentration of biological liquids (diluted serum) was studied. © 1994 John Wiley & Sons, Inc.