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Strong buffering characteristics and swelling behavior of cationic copolymers
Author(s) -
Peppas Nikolaos A.,
Foster Lisa K.
Publication year - 1994
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1994.070520606
Subject(s) - comonomer , cationic polymerization , swelling , copolymer , polymer chemistry , methacrylate , ionic strength , ionic bonding , polymer , chemistry , chloride , materials science , chemical engineering , organic chemistry , ion , composite material , aqueous solution , engineering
Abstract The swelling behavior of crosslinked cationic copolymers of 2‐hydroxyethyl methacrylate with (3‐methacryloylamino propyl) trimethylammonium chloride was investigated in various buffered solutions as a function of ionic strength and pH. The equilibrium degree of swelling increased as the pH decreased or as the cationic group‐containing comonomer in the polymer increased. The water transport in such copolymers was controlled by a non‐Fickian mechanism. These results can be used in the development of physiologically sensitive controlled drug delivery systems. © 1994 John Wiley & Sons, Inc.