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Drug‐release behavior of polyurethane microspheres
Author(s) -
Shantha K. L.,
Rao K. Panduranga
Publication year - 1993
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1993.070501102
Subject(s) - polyurethane , bromothymol blue , isocyanate , materials science , microsphere , scanning electron microscope , polymerization , chemical engineering , polymer chemistry , nuclear chemistry , chemistry , composite material , organic chemistry , polymer , engineering
Polyurethane (PU) microspheres were prepared by a novel and simple method using the condensation polymerization technique. Microspheres of different morphological characteristics were prepared using tolylene 2,4‐diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). These microspheres were fully characterized by thermal analysis, scanning electron microscopy, and spectral techniques. MDI‐containing microspheres were found to be more porous as compared to TDI‐containing microspheres. The infrared spectra indicated the complete utilization of the isocyanate groups in the synthesis of microspheres. Bromothymol Blue (BTB) was used as a model drug for the in vitro release studies from the spheres. The results indicated that BTB released much faster using the MDI spheres as compared to the TDI spheres. © 1993 John Wiley & Sons, Inc.