Premium
DAC‐coated resins for hemoperfusion
Author(s) -
Yan Jun,
Xu Rongnan,
Zhou Peiqing,
Lu Zhounian,
Wu Xinhua,
Wu Zhaoguang
Publication year - 1992
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1992.070460807
Subject(s) - hemoperfusion , pentobarbital , coating , raw material , adsorption , phenobarbital , acrylic resin , chemistry , chromatography , materials science , nuclear chemistry , anesthesia , medicine , pharmacology , organic chemistry , surgery , hemodialysis
This paper reports the use of diacetylchitin (DAC)‐coated macroreticular resin HS‐12 as an adsorbent in hemoperfusion. Sixteen dogs acutely intoxicated with pentobarbital were hemoperfused, either with the coated resin (n = 8) or raw resin (n = 8). The results showed the coating greatly improved resin hemocompatibility. The clearance rates for the coated and raw resins were 195 mL/min for the first 5 min at a flow rate of 200 mL/min. In clinical practice, 12 patients who were acutely intoxicated by drugs, such as pentobarbital and phenobarbital, were hemoperfused and saved. © 1992 John Wiley & Sons, Inc.