Premium
Studies on modified chitosan membranes. II. Dialysis of low molecular weight metabolites
Author(s) -
Qurashi M. T.,
Blair H. S.,
Allen S. J.
Publication year - 1992
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1992.070460207
Subject(s) - membrane , permeation , chitosan , chemistry , urea , dialysis , aqueous solution , chromatography , uric acid , nuclear chemistry , polymer chemistry , chemical engineering , organic chemistry , biochemistry , surgery , medicine , engineering
The permeabilities of low molecular weight metabolites were determined through chitosan and a series of chitosan—poly(vinyl pyrrolidone) (PVP) membranes. The dialysis studies were carried out in vitro using a diaphragm‐type test cell. The basic metabolites (urea, creatinine, and glucose) show higher permeation rates than do the acidic metabolites (uric acid and phosphate) through all the modified membranes. The hydrophilicity of the membranes, molecular weight, and chemical nature of the metabolites were important parameters in determining transport properties of the membranes. It was observed that higher permeation rates can be obtained by manipulating the amount of PVP in the blended membranes. The PVP weight loss in the aqueous medium was negligible.