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New macromolecular carriers for drugs. I. Preparation and characterization of poly(oxyethylene‐ b ‐isoprene‐ b ‐oxyethylene) block copolymer aggregates
Author(s) -
Rolland A.,
O'Mullane J.,
Goddard P.,
Brookman L.,
Petrak K.
Publication year - 1992
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1992.070440709
Subject(s) - copolymer , isoprene , micelle , polymerization , polymer chemistry , materials science , styrene , drug delivery , drug carrier , macromolecule , chemistry , organic chemistry , polymer , nanotechnology , aqueous solution , biochemistry
This work describes the formation of discrete micelles (⋍ 0.1 μm) from ABA poly(oxyethylene‐ b ‐isoprene‐ b ‐oxyethylene) block copolymers in water. An efficient labeling of the micelles by polymerization of [ 14 C]‐styrene within the hydrophobic core is also described. These micellar nanoparticles are being considered as promising materials for controlled release and/or site‐specific drug delivery systems. In experimental animals the micelles remained in circulation with a half‐life in excess of 50 h. Our results demonstrate the advantages of using block copolymers for the preparation of “perfect” biocompatible surfaces such as are required for well‐tolerated, long‐circulating particulate drug carriers.