Premium
Application of a macromolecular Sn (II) complex to the preparation of 99m Tc radiopharmaceuticals
Author(s) -
Nakayama Morio,
Terahara Takaaki,
Wada Masao,
Harada Kumiko,
Sugii Atsushi,
Egawa Hiroaki
Publication year - 1991
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1991.070431212
Subject(s) - macromolecule , chelation , adsorption , hydrolysis , chemistry , ion exchange resin , nuclear chemistry , inorganic chemistry , polymer chemistry , organic chemistry , biochemistry
To develop insoluble Sn 2+ complexes for the preparation of 99m Tc radiopharmaceuticals, the adsorption of Sn 2+ to macroreticular chelating ion exchange resins having various functional groups was investigated. Among them, a resin containing aminophosphonic acid groups showed a high adsorption capacity for Sn 2+ , which was bound strongly to the resin by chelation. This macromolecular Sn 2+ complex was very stable against hydrolysis and oxidation, and could be applied satisfactorily for the reduction of 99m Tc.