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SSIMS analysis of methacrylate copolymers employed in drug delivery
Author(s) -
Wilding Ian R.,
Melia Colin D.,
Short Robert D.,
Davies Martyn C.,
Brown Alan
Publication year - 1990
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1990.070390901
Subject(s) - copolymer , methacrylate , secondary ion mass spectroscopy , monomer , materials science , drug delivery , polymer chemistry , secondary ion mass spectrometry , mass spectrometry , chemical engineering , polymer , chemistry , nanotechnology , chromatography , composite material , silicon , engineering , metallurgy
This study reports on the use of static secondary ion mass spectroscopy (SSIMS) to chemically characterize complex methacrylate copolymers used in the pharmaceutical industry for controlled drug delivery. Ions diagnostic of the component monomer residues were detected, which could be interpreted using a fragmentation model for alkylmethacrylate homopolymers proposed previously. This model is extended to include the SSIMS analysis of nitrogen‐containing methacrylate copolymer residues.