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Synthesis of bioactive 2,2‐dichloropropionic acid esters of carboxymethyl cellulose and investigations on their release behavior
Author(s) -
Schnabelrauch Matthias,
Geschwend Günter,
Klemm Dieter
Publication year - 1990
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1990.070390312
Subject(s) - carboxymethyl cellulose , hydrolysis , cellulose , polymer , chemistry , organic chemistry , polymer chemistry , sodium
Abstract Polymer bound bioactive agents are prepared by linking 2,2‐dichloropropionic acid to the hydroxyl groups of carboxymethyl cellulose (CMC) and enzymatically cleavable CMC networks, and to the carboxyl groups of CMC via enzymatically cleavable spacer units using a simple as well as effective CMC activation procedure. The hydrolytic release of the bioactive agent is mainly dependent on the hydrophilicity of the CMC esters. In the case of polymers containing enzymatically cleavable structural units the release can be accelerated by addition of esterases.