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Preparation, characterization, and properties of polylactide (PLA)–poly(ethylene glycol) (PEG) copolymers: A potential drug carrier
Author(s) -
Zhu K. J.,
Xiangzhou Lin,
Shilin Yang
Publication year - 1990
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1990.070390101
Subject(s) - copolymer , ethylene glycol , peg ratio , polyethylene glycol , materials science , polymer , polymer chemistry , drug carrier , biodegradable polymer , polyester , polymerization , lactide , drug delivery , organic chemistry , chemistry , nanotechnology , finance , economics , composite material
Polylactide (PLA)‐poly(ethylene glycol) (PEG) copolymers were synthesized from polyethylene glycol and D , L ‐lactide using low toxic stannous octoate as catalyst at 180°C by bulk polymerization. The copolymers were characterized by GPC, IR, and 13 C‐NMR. A full assignment NMR spectrum is presented. The physical, drug release, and biodegradable properties in vitro of PLA–PEG copolymers were investigated. The result indicates that the rates of drug release and biodegradation could be tailored by adjusting polymer composition. This amorphous material might be used as a drug carrier in medical applications.