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Effects of low levels of methacrylic acid on the swelling behavior of poly(2‐hydroxyethyl methacrylate)
Author(s) -
Pinchuk L.,
Eckstein E. C.,
Van De Mark M. R.
Publication year - 1984
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1984.070290528
Subject(s) - swelling , methacrylate , distilled water , self healing hydrogels , methacrylic acid , 2 hydroxyethyl methacrylate , polymer chemistry , urea , materials science , chemistry , biomaterial , chemical engineering , swell , nuclear chemistry , chromatography , copolymer , composite material , organic chemistry , polymer , oceanography , engineering , geology
The effects of low levels of methacrylic acid (MAA) (less than 4 mol %) and a crosslinker (less than 0.3 mol %) on the equilibrium swelling and water content of poly(2‐hydroxyethyl methacrylate) (pHEMA) hydrogels were investigated. Numerous pHEMA disks, some of which were doped with small amounts of MAA, were placed in swelling baths simulating possible urological as well as physiological conditions. Several interesting facts are reported, such as, in dilute urea (0.15 M ) or in alkali solution, gels containing 2% MAA are capable of swelling to 3600% their size in mild acid, saline, or distilled water, with associated water contents that range as high as 98%. Also, gels containing small amounts of MAA and finite crosslinker content can be made that are soluble in mild urea or alkali solution. The significance of this study is that gels or gel surfaces can be fabricated that are highly responsive to their environment. In addition, since the level of MAA that cause this shrink–swell behavior are well within the impurity levels of MAA found in unpurified commercial HEMA, it is conceivable that this shrink–swell behavior may have occurred in early studies of implanted pHEMA gels, thus confusing the subsequent evaluation of its performance as a biomaterial.