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Rigid polar composite supports for use in solid phase synthesis
Author(s) -
Akelah A.,
Heffernan J. G.,
Kingston S. B.,
Sherrington D. C.
Publication year - 1983
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1983.070281012
Subject(s) - composite number , polypropylene , polystyrene , materials science , polyethylene , polyamide , yield (engineering) , phase (matter) , composite material , polar , polymer , chemical engineering , polymer chemistry , organic chemistry , chemistry , physics , astronomy , engineering
A number of particulate polyethylene and polypropylene based matrices have been γ ‐radiation grafted with poly(acryloylsarcosine methyl ester). The resulting composite materials have physicochemical properties attractive for use in continuous solid phase synthesis. Three macroporous polystyrene resins have also been impregnated with a secondary polyamide network using thermal initiation. All of these retain their rigid spherical structure and the composite properties again make them good candidates for use under pressure. One of these has been used in a preliminary solid phase experiment and two successive amino acid residues coupled with ∼100% yield.