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The determination of particle size distribution by hydrodynamic chromatography. An analysis of dispersion and methods for improved signal resolution
Author(s) -
Silebi C. A.,
McHugh A. J.
Publication year - 1979
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1979.070230612
Subject(s) - dispersion (optics) , resolution (logic) , particle size , optics , refractive index , gaussian , mie scattering , particle (ecology) , dispersity , particle size distribution , light scattering , polynomial , range (aeronautics) , scattering , materials science , stability (learning theory) , computational physics , physics , chemistry , mathematics , mathematical analysis , oceanography , composite material , quantum mechanics , artificial intelligence , machine learning , computer science , polymer chemistry , geology
Various methods are described and compared for the determination of particle size distributions (PSD) in the submicron range by a technique known as hydrodynamic chromatography (HDC). Data are presented for a series of monodisperse latexes to establish the validity of the Mie theory of light scattering in describing the detector optical density signal. Analyses for the PSD involve corrections to the experimental HDC chromatograms for the effects of dispersion and are broadly classified as integral and numerical methods. Comparisons of calculations are made to chromatograms for polydisperse latexes as well as synthetic, discontinuous distributions and show the critical role of the optical density–particle size relationship in determining resolution and calculation stability. An integral method involving a non‐Gaussian form for the dispersion function and a polynomial expansion for the chromatogram and an iterative numerical method involving modifications of a previously published technique are shown to give the best results for the PSD. The discussion includes an analysis of the possibility of improved signal resolution using turbidity in the absorption wavelength region and refractive index measurements. The conclusion is reached that increased resolution with turbidity is preferable to refractive index measurement since lower particle concentrations can be used.